The GPNMB Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody to glycoprotein nmb, and Gpnmb. This antibody recognizes Human, Mouse, and Rat antigen. The GPNMB Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated has been validated for the following applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, and Immunohistochemistry - frozen.
Description
The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]